Transfusion Medicine Reviews
Volume 17, Issue 1 , Pages 31-44 , January 2003

Prenatal typing of Rh and kell blood group system antigens: The edge of a watershed

  • C. Ellen van der Schoot

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Division, CLB, Academic Medical Center, University of Amsterdam Amsterdam, The Netherlands
    • Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherland
    • Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    • Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, The Netherlands
    • Corresponding Author InformationAddress reprint requests to C. Ellen van der Schoot, MD, PhD, Department of Experimental Immunohematology, Sanquin, Division CLB, Plesmanlaan 10, 1066 CX Amsterdam, The Netherlands.
    • ,
  • G.H. Martine Tax

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Division, CLB, Academic Medical Center, University of Amsterdam Amsterdam, The Netherlands
    • Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherland
    • Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    • Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, The Netherlands
    • ,
  • Robbert J.P. Rijnders

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Division, CLB, Academic Medical Center, University of Amsterdam Amsterdam, The Netherlands
    • Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherland
    • Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    • Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, The Netherlands
    • ,
  • Masja de Haas

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Division, CLB, Academic Medical Center, University of Amsterdam Amsterdam, The Netherlands
    • Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherland
    • Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    • Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, The Netherlands
    • ,
  • Godelieve C.M.L. Christiaens

      Affiliations

    • Department of Experimental Immunohematology, Sanquin Division, CLB, Academic Medical Center, University of Amsterdam Amsterdam, The Netherlands
    • Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherland
    • Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    • Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, The Netherlands

References 

  1. van Kamp IL, Klumper FJ, Meerman RH, et al. Blood group immunization: results of treatment of fetal anemia with intra-uterine intravascular blood transfusion in the Netherlands, 1987–1995. Ned Tijdschr Geneeskd. 1999;143:2527–2531
  2. Nicolaides KH, Rodeck CH. Maternal serum anti-D antibody concentration and assessment of rhesus isoimmunisation. BMJ. 1992;304:1155–1156
  3. Oepkes D, van Kamp IL, Simon MJ, et al. Clinical value of an antibody-dependent cell-mediated cytotoxicity assay in the management of Rh D alloimmunization. Am J Obstet Gynecol. 2001;184:1015–1020
  4. Gemke RJ, Kanhai HH, Overbeeke MA, et al. ABO and Rhesus phenotyping of fetal erythrocytes in the first trimester of pregnancy. Br J Haematol. 1986;64:689–697
  5. Marini AM, Urrestarazu A, Beauwens R, et al. The Rh (rhesus) blood group polypeptides are related to NH4+ transporters. Trends Biochem Sci. 1997;22:460–461
  6. Marini A-M, Matassi G, Raynal V, et al. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet. 2000;26:341–344
  7. Colin Y, Cherif-Zahar B, Le Van Kim C, et al. Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis. Blood. 1991;78:2747–2752
  8. Wagner FF, Flegel WA. RHD gene deletion occurred in the Rhesus box. Blood. 2000;95:3662–3668
  9. Avent ND, Reid ME. The Rh blood group system: A review. Blood. 2000;95:375–387
  10. Faas BHW, Beckers EAM, Wildoer P, et al. Molecular background of VS and weak C expression in blacks. Transfusion. 1997;37:38–44
  11. Singleton BK, Green CA, Avent ND, et al. The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in africans with the Rh D-negative blood group phenotype. Blood. 2000;95:12–18
  12. Tax GHM, van der Schoot CE, van Doorn R, et al: Rhesus C and c genotyping in different ethnic groups. Transfusion (in press)
  13. Available at Accessed October 1, 2002 Wagner FF, Frohmajer A, Flegel WA. RHD positive haplotypes in D negative Europeans.
  14. Okuda H, Kawano M, Iwamoto S, et al. The RHD gene is highly detectable in RhD-negative Japanese donors. J Clin Invest. 1997;100:373–379
  15. Hemker MB, Ligthart PC, Berger L, et al. DAR, a new RhD variant involving exons 4, 5 and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks. Blood. 1999;94:4337–4342
  16. Wolter LC, Hyland CA, Saul A. Rhesus D genotyping using polymerase chain reaction. Blood. 1993;82:1682–1683
  17. Bennett PR, Le Van Kim C, Colin Y, et al. Prenatal determination of fetal RhD type by DNA amplification. N Engl J Med. 1993;329:607–610
  18. Arce MA, Thompson ES, Wagner S, et al. Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals. Blood. 1993;82:651–655
  19. Simsek S, Bleeker PM, von dem Borne AE. Prenatal determination of fetal RhD type. N Engl J Med. 1994;330:795–796
  20. Simsek S, Faas BH, Bleeker PM, et al. Rapid Rh D genotyping by polymerase chain reaction-based amplification of DNA. Blood. 1995;85:2975–2980
  21. Pope J, Navarrete C, Warwick R, et al. Multiplex PCR analysis of RhD gene. Lancet. 1995;346:375–376
  22. Aubin JT, Le Van Kim C, Mouro I, et al. Specificity and sensitivity of RHD genotyping methods by PCR-based DNA amplification. Br J Haematol. 1997;98:356–364
  23. Gassner C, Schmarda A, Kilga-Nogler S, et al. RHD/CE typing by polymerase chain reaction using sequence-specific primers. Transfusion. 1997;37:1020–1026
  24. Maaskant-van Wijk PA, Faas BH, de Ruijter JA, et al. Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons. Transfusion. 1998;38:1015–1021
  25. Legler TJ, Maas JH, Kohler M, et al. RHD sequencing: A new tool for decision making on transfusion therapy and provision of Rh prophylaxis. Transfus Med. 2001;11:383–388
  26. Lo YM, Hjelm NM, Fidler C, et al. Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med. 1998;339:1734–1738
  27. Avent ND, Finning KM, Martin PG, et al. Prenatal determination of fetal blood group status. Vox Sang. 2000;78(suppl):155–162
  28. Zhong XY, Holzgreve W, Hahn S. Risk free simulta neous prenatal identification of fetal Rheusus D status and sex by multiplex real-time PCR using cell free fetal DNA in maternal plasma. Swiss Med Wkly. 2001;131:70–74
  29. Heid CA, Stevens J, Livak KJ, et al. Real time quantitative PCR. Genome Res. 1996;6:986–994
  30. Kemp TJ, Poulter M, Carritt B. Microsatellite variation within the human RHCE gene. Vox Sang. 1999;77:159–163
  31. Huang CH, Reid ME, Chen Y, et al. Molecular definition of red cell Rh haplotypes by tightly linked SphI RFLPs. Am J Hum Genet. 1996;58:133–142
  32. Fujiwara H, Okuda H, Omi T, et al. The STR polymorphisms in intron 8 may provide information about the molecular evolution of RH haplotypes. Hum Genet. 1999;104:301–306
  33. Chan FY, Cowley NM, Wolter L, et al. Prenatal RHD gene determination and dosage analysis by PCR: Clinical evaluation. Prenat Diagn. 2001;21:321–326
  34. Cossu G, Angius A, Gelfi C, et al. Rh D/d genotyping by quantitative polymerase chain reaction and capillary zone electrophoresis. Electrophoresis. 1996;17:1911–1915
  35. Chiu RW, Murphy MF, Fidler C, Wainscoat JS, et al. Technical optimization of RhD zygosity determination by realtime quantitative polymerase chain reaction: Implication for fetal RhD status determination by maternal plasma. Ann N Y Acad Sci. 2001;945:156–160
  36. Chiu RW, Murphy MF, Fidler C, et al. Determination of RhD zygosity: Comparison of a double amplification refractory mutation system approach and a multiplex real-time quantitative PCR approach. Clin Chem. 2001;47:667–672
  37. Mouro I, Colin Y, Cherif-Zahar B, et al. Molecular genetic basis of the human Rhesus blood group system. Nat Genet. 1993;5:62–65
  38. Simsek S, de Jong CAM, Cuijpers HM, et al. Sequence analysis of cDNA derived from reticulocyte mRNAs coding for Rh polypeptides and demonstration of E/e and C/c polymorphisms. Vox Sang. 1994;67:203–209
  39. Poulter M, Kemp TJ, Carrit B. DNA-based Rhesus typing: Simultaneous determination of the RHC and RHD status using the polymerase chain reaction. Vox Sang. 1996;70:164–168
  40. Salvignol I, Calvas P, Socha WW, et al. Structural analysis of the RH-like blood group gene products in nonhuman primates. Immunogenetics. 1995;41:271–281
  41. Westhoff CM, Silberstein LE, Wylie DE. Evidence supporting the requirement for two proline residues for expression of c. Transfusion. 2000;40:321–324
  42. Faas BHW, Beuling EA, Ligthart PC. Partial expresson of Rhesus c on the Rhesus D polypeptide. Transfusion. 2001;41:1136–1142
  43. Smythe JS, Anstee DJ. Expression of C antigen in transduced K562 cells. Transfusion. 2001;41:24–30
  44. Faas BH, Simsek S, Bleeker PM, et al. Rh E/e genotyping by allele-specific primer amplification. Blood. 1995;85:829–832
  45. Le Van Kim C, Mouro I, Brossard Y, et al. PCR-based determination of Rhc and RhE status of fetuses at risk of Rhc and RhE haemolytic disease. Br J Haematol. 1994;88:193–195
  46. Avent ND. Antenatal genotyping of the blood groups of the fetus. Vox Sang. 1998;74(suppl):365–374
  47. Faas BH, Maaskant-Van Wijk PA, von dem Borne AE, et al. The applicability of different PCR-based methods for fetal RHD and K1 genotyping: A prospective study. Prenat Diagn. 2000;20:453–458
  48. Faas BHW, Beckers EAM, Wildoer P, et al. Molecular background of VS and weak C expression in blacks. Transfusion. 1997;37:38–44
  49. Spence WC, Potter P, Maddalena A, et al. DNA-based prenatal determination of the RhEe genotype. Obstet Gynecol. 1995;86:670–672
  50. Geifman-Holtzman O, Bernstein IM, Berry SM, et al. Rapid molecular determination of fetal rhesus E type. Prenat Diagn. 1996;16:489–493
  51. Yankowitz J, Li S, Weiner CP. Polymerase chain reaction determination of RhC, Rhc, and RhE blood types: An evaluation of accuracy and clinical utility. Am J Obstet Obstet Gynecol. 1997;176:1107–1111
  52. Lee S, Lin M, Mele A, et al. Proteolytic processing of big endothelin-3 by the kell blood group protein. Blood. 1999;94:1440–1450
  53. Bowman JM, Pollock JM, Manning FA, et al. Maternal Kell blood group alloimmunization. Obstet Gynecol. 1992;79:239–244
  54. Lee S, Wu X, Reid M, et al. Molecular basis of the Kell (K1) phenotype. Blood. 1995;85:912–916
  55. Vaughan JI, Manning M, Warwick RM, et al. Inhibition of erythroid progenitor cells by anti-Kell antibodies in fetal alloimmune anemia. N Engl J Med. 1998;338:798–803
  56. Wagner T, Berer A, Lanzer G, et al. Kell is not restricted to the erythropoietic lineage but is also expressed on myeloid progenitor cells. Br J Haematol. 2000;110:409–411
  57. Wagner T, Bernaschek G, Geissler K. Inhibition of megakaryopoiesis by Kell-related antibodies. N Engl J Med. 2000;343:72
  58. Lee S, Bennett PR, Overton T, et al. Prenatal diagnosis of Kell blood group genotypes: KEL1 and KEL2. Am J Obstet Gynecol. 1996;175:455–459
  59. Hessner MJ, McFarland JG, Endean DJ. Genotyping of KEL1 and KEL2 of the human Kell blood group system by the polymerase chain reaction with sequence-specific primers. Transfusion. 1996;36:495–499
  60. Murphy MT, Fraser RH, Goddard JP. Development of a PCR-based diagnostic assay for the determination of KEL genotype in donor blood samples. Transfus Med. 1996;6:133–137
  61. Avent ND, Martin PG. Kell typing by allele-specific PCR (ASP). Br J Haematol. 1996;93:728–730
  62. Lighten AD, Overton TG, Sepulveda W, et al. Accuracy of prenatal determination of RhD type status by polymerase chain reaction with amniotic cells. Am J Obstet Gynecol. 1995;173:1182–1185
  63. Fisk NM, Bennett P, Warwick RM, et al. Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi. Am J Obstet Gynecol. 1994;171:50–54
  64. Rossiter JP, Blakemore KJ, Kickler TS, et al. The use of polymerase chain reaction to determine fetal RhD status. Am J Obstet Gynecol. 1994;171:1047–1051
  65. Van Den Veyver IB, Subramanian SB, Hudson KM, et al. Prenatal diagnosis of the RhD fetal blood type on amniotic fluid by polymerase chain reaction. Obstet Gynecol. 1996;87:419–422
  66. Crombach G, Picard F, Beckmann M, et al. Fetal Rhesus D genotyping on amniocytes in alloimmunised pregnancies. Br J Obstet Gynaecol. 1997;104:15–19
  67. Heckerling PS, Verp MS. Amniocentesis or chorionic villus sampling for prenatal genetic testing: A decision analysis. J Clin Epidemiol. 1991;44:457–470
  68. Schmorl G. Pathologisch-anatomische untersuchungen ueber Publereklampsie. Leipzig: Vogel; 1893;
  69. Bianchi DW. Fetal cells in the maternal circulation: Feasibility for prenatal diagnosis. Br J Haematol. 1999;105:574–583
  70. Lo YM, Patel P, Wainscoat JS, et al. Prenatal sex determination by DNA amplification from maternal peripheral blood. Lancet. 1989;2:1363–1365
  71. Lo YM, Bowell PJ, Selinger M, et al. Prenatal determination of fetal RhD status by analysis of peripheral blood of rhesus negative mothers. Lancet. 1993;341:1147–1148
  72. Lo YM, Noakes L, Bowell PJ, et al. Detection of fetal RhD sequence from peripheral blood of sensitized RhD-negative pregnant women. Br J Haematol. 1994;87:658–660
  73. Geifman-Holtzman O, Bernstein IM, Berry SM, et al. Fetal RhD genotyping in fetal cells flow sorted from maternal blood. Am J Obstet Gynecol. 1996;174:818–822
  74. Sekizawa A, Watanabe A, Kimura T, et al. Prenatal diagnosis of the fetal RhD blood type using a single fetal nucleated erythrocyte from maternal blood. Obstet Gynecol. 1996;87:501–505
  75. Hamlington J, Cunningham J, Mason G, et al. Prenatal detection of rhesus D genotype. Lancet. 1997;349:540
  76. Bianchi DW, Williams JM, Sullivan LM, et al. PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies. Am J Hum Genet. 1997;61:822–829
  77. Bianchi DW, Zickwolf GK, Weil GJ, et al. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci U S A. 1996;93:705–708
  78. van Wijk IJ, van Vugt JM, Mulders MA, et al. Enrichment of fetal trophoblast cells from the maternal peripheral blood followed by detection of fetal deoxyribonucleic acid with a nested X/Y polymerase chain reaction. Am J Obstet Gynecol. 1996;174:871–878
  79. Sargent IL, Johansen M, Chua S, et al. Clinical experience: Isolating trophoblasts from maternal blood. Ann N Y Acad Sci. 1994;731:154–161
  80. Slunga-Tallberg A, el-Rifai W, Keinanen M, et al. Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women. Hum Genet. 1995;96:53–57
  81. Mesker WE, Ouwerkerk-van Velzen MC, Oosterwijk JC, et al. Two-colour immunocytochemical staining of gamma (gamma) and epsilon (epsilon) type haemoglobin in fetal red cells. Prenat Diagn. 1998;18:1131–1137
  82. Zheng YL, Demaria M, Zhen D, et al. Flow sorting of fetal erythroblasts using intracytoplasmic anti-fetal haemoglobin: preliminary observations on maternal samples. Prenat Diagn. 1995;15:897–905
  83. Jansen MW, Brandenburg H, Wildschut HI, et al. The effect of chorionic villus sampling on the number of fetal cells isolated from maternal blood and on maternal serum alphafetoprotein levels. Prenat Diagn. 1997;17:953–959
  84. Al-Mufti R, Howard C, Overton T, et al. Detection of fetal messenger ribonucleic acid in maternal blood to determine fetal RhD status as a strategy for noninvasive prenatal diagnosis. Am J Obstet Gynecol. 1998;179:210–214
  85. Cunningham J, Yates Z, Hamlington J, et al. Non-invasive RNA-based determination of fetal Rhesus D type: A prospective study based on 96 pregnancies. Br J Obstet Gynaecol. 1999;106:1023–1028
  86. Nawroz H, Koch W, Anker P, et al. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med. 1996;2:1035–1037
  87. Chen XQ, Stroun M, Magnenat JL, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med. 1996;2:1033–1035
  88. Lo YM, Corbetta N, Chamberlain PF, et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350:485–487
  89. Lo YM, Tein MS, Lau TK, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: Implications for noninvasive prenatal diagnosis. Am J Hum Genet. 1998;62:768–775
  90. Leung TN, Zhang J, Lau TK, et al. Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin Chem. 2001;47:137–139
  91. Lo YM, Lau TK, Zhang J, et al. Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21. Clin Chem. 1999;45:1747–1751
  92. Zhong XY, Burk MR, Troeger C, et al. Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses. Prenat Diagn. 2000;20:795–798
  93. Chiu RW, Poon LL, Lau TK, et al. Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma. Clin Chem. 2001;47:1607–1613
  94. Sekizawa A, Samura O, Zhen DK, et al. Apoptosis in fetal nucleated erythrocytes circulating in maternal blood. Prenat Diagn. 2000;20:886–889
  95. van Wijk IJ, de Hoon AC, Jurhawan R, et al. Detection of apoptotic fetal cells in plasma of pregnant women. Clin Chem. 2000;46:729–731
  96. Lo YM, Zhang J, Leung TN, et al. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Gent. 1999;64:218–224
  97. Bianchi DW. Fetal DNA in maternal plasma: the plot thickens and the placental barrier thins. Am J Hum Genet. 1998;62:763–764
  98. Poon LL, Lo YM. Circulating fetal DNA in maternal plasma. Clin Chim Acta. 2001;313:151–155
  99. Hahn S, Zhong XY, Burk MR, et al. Both maternal and fetal cell-free DNA in plasma fluctuate. Ann N Y Acad Sci. 2001;945:141–144
  100. Rijnders RJ, van der Schoot CE, Bossers B, et al. Fetal sex determination from maternal plasma in pregnancies at risk for congenital adrenal hyperplasia. Obstet Gynecol. 2001;98:374–378
  101. Amicucci P, Gennarelli M, Novelli G, et al. Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma. Clin Chem. 2000;46:301–302
  102. Saito H, Sekizawa A, Morimoto T, et al. Prenatal DNA diagnosis of a single-gene disorder from maternal plasma. Lancet. 2000;356:1170
  103. Skinner J, Luettich K, Ring M, et al. Fetal DNA in maternal circulation of first-trimester spontaneous abortions. Obstet Gynecol. 2001;97:460–463
  104. Al-Yatama MK, Mustafa AS, Ali S, et al. Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction. Prenat Diagn. 2001;21:399–402
  105. Wei C, Saller DN, Sutherland JW. Detection and quantification by homogeneous PCR of cell-free fetal DNA in maternal plasma. Clin Chem. 2001;47:336–338
  106. Costa JM, Benachi A, Gautier E, et al. First-trimester fetal sex determination in maternal serum using real-time PCR. Prenat Diagn. 2001;21:1070–1074
  107. Ohashi Y, Miharu N, Honda H, et al. Quantitation of fetal DNA in maternal serum in normal and aneuploid prenancies. Hum Genet. 2001;108:123–127
  108. Honda H, Miharu N, Ohashi Y, et al. Successful diagnosis of fetal gender using conventional PCR analysis of maternal serum. Clin Chem. 2001;47:41–46
  109. Faas BH, Beuling EA, Christiaens GC, et al. Detection of fetal RHD-specific sequences in maternal plasma. Lancet. 1998;352:1196–1197
  110. Lo YM, Hjelm NM, Fidler C, et al. Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med. 1998;339:1734–1738
  111. suppl abstr Rouillac C, Puillandre P, Colin Y, et al. Fetal RHD typing using DNA isolated from maternal plasma: A prediagnosis study on 182 cases. Vox Sang. 2000;78:O026
  112. Zhong XY, Holzgreve W, Hahn S. Detection of fetal Rhesus D and sex using fetal DNA from maternal plasma by multiplex polymerase chain reaction. BJOG. 2000;107:766–769
  113. Bischoff FZ, Nguyen DD, Marquez-Do D, et al. Noninvasive determination of fetal RhD status using fetal DNA in maternal serum and PCR. J Soc Gynecol Investig. 1999;6:64–69
  114. Lacey PA, Caskey CR, Werner DJ, et al. Fatal hemolytic disease of a newborn due to anti-D in an Rh-positive Du variant mother. Transfusion. 1998;23:91–94
  115. Thiede C, Bornhauser M, Oelschlagel U, et al. Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR amplification of short tandem repeat-markers. Leukemia. 2001;15:293–302
  116. Pertl B, Sekizawa A, Samura O, et al. Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amplification of short tandem repeats. Hum Genet. 2000;106:45–49
  117. Tang NL, Leung TN, Zhang J, et al. Detection of fetal-derived paternally inherited X-chromosome polymorphisms in maternal plasma. Clin Chem. 1999;45:2033–2035
  118. (abstr) Finning KM, Martin PG, Soothill P, et al. Non-invasive prenatal diagnosis of fetal blood group status. Transfus Med. 1999;9:23
  119. Vervoordeldonk SF, Doumaid K, Remmerswaal EB, et al. Long-term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion. Br J Haematol. 1998;102:1004–1009

PII: S0887-7963(03)80003-2

doi: 10.1053/tmrv.2003.50001

Transfusion Medicine Reviews
Volume 17, Issue 1 , Pages 31-44 , January 2003

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