Transfusion Medicine Reviews
Volume 21, Issue 1 , Pages 1-12 , January 2007

Acetaminophen and Diphenhydramine Premedication for Allergic and Febrile Nonhemolytic Transfusion Reactions: Good Prophylaxis or Bad Practice?

  • Terrence L. Geiger

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Terrence L. Geiger, MD, PhD, Department of Pathology, St Jude Children's Research Hospital, 332 N. Lauderdale St, D-4047, Memphis, TN 38105.
    • ,
  • Scott C. Howard

References 

  1. Ezidiegwu CN, Lauenstein KJ, Rosales LG, et al. Febrile nonhemolytic transfusion reactions. Management by premedication and cost implications in adult patients. Arch Pathol Lab Med. 2004;128:991–995
  2. Patterson BJ, Freedman J, Blanchette V, et al. Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions. Transfus Med. 2000;10:199–206
  3. Sanders RP, Maddirala SD, Geiger TL, et al. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol. 2005;130:781–787
  4. Yazer MH, Podlosky L, Clarke G, et al. The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC. Transfusion. 2004;44:10–15
  5. Paglino JC, Pomper GJ, Fisch GS, et al. Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction. Transfusion. 2004;44:16–24
  6. King KE, Shirey RS, Thoman SK, et al. Universal leukoreduction decreases the incidence of febrile nonhemolytic transfusion reactions to RBCs. Transfusion. 2004;44:25–29
  7. Ibojie J, Greiss M, Urbaniak SJ. Limited efficacy of universal leucodepletion in reducing the incidence of febrile non-haemolytic reactions in red cell transfusion. Transfus Med. 2002;12:387–389
  8. Pitocco C, Sexton TR. Alleviating blood shortages in a resource-constrained environment. Transfusion. 2005;45:1118–1126
  9. Sullivan MT, Wallace EL. Blood collection and transfusion in the United States in 1999. Transfusion. 2005;45:141–148
  10. Heddle NM. Pathophysiology of febrile nonhemolytic transfusion reactions. Curr Opin Hematol. 1999;6:420–426
  11. Stack G, Snyder EL. Cytokine generation in stored platelet concentrates. Transfusion. 1994;34:20–25
  12. Heddle NM, Klama L, Singer J, et al. The role of the plasma from platelet concentrates in transfusion reactions. N Engl J Med. 1994;331:625–628
  13. Muylle L, Laekeman G, Herman AG, et al. Histamine levels in stored platelet concentrates. Relationship to white cell content. Transfusion. 1988;28:226–228
  14. Stack G, Baril L, Napychank P, et al. Cytokine generation in stored, white cell–reduced, and bacterially contaminated units of red cells. Transfusion. 1995;35:199–203
  15. Wadhwa M, Seghatchian MJ, Dilger P, et al. Cytokines in WBC-reduced apheresis PCs during storage: A comparison of two WBC-reduction methods. Transfusion. 2000;40:1118–1126
  16. Schleuning M, Bock M, Mempel W. Complement activation during storage of single-donor platelet concentrates. Vox Sang. 1994;67:144–148
  17. Gyongyossy-Issa MI, McLeod E, Devine DV. Complement activation in platelet concentrates is surface-dependent and modulated by the platelets. J Lab Clin Med. 1994;123:859–868
  18. Takahashi TA, Abe H, Hosoda M, et al. Bradykinin generation during filtration of platelet concentrates with a white cell-reduction filter. Transfusion. 1995;35:967
  19. Brittingham TE, Chaplin H. Febrile transfusion reactions caused by sensitivity to donor leukocytes and platelets. JAMA. 1957;165:819–825
  20. de Rie MA, van der Plas-van Dalen CM, Engelfriet CP, et al. The serology of febrile transfusion reactions. Vox Sang. 1985;49:126–134
  21. Domen RE, Hoeltge GA. Allergic transfusion reactions: an evaluation of 273 consecutive reactions. Arch Pathol Lab Med. 2003;127:316–320
  22. Janeway CA, Travers P, Walport M, et al. Immunobiology. 6 ed.. New York: Garland Science; 2005;
  23. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: A comprehensive review of the literature. Respir Res. 2003;4:14
  24. Gilstad CW. Anaphylactic transfusion reactions. Curr Opin Hematol. 2003;10:419–423
  25. Lambin P, Le Pennec PY, Hauptmann G, et al. Adverse transfusion reactions associated with a precipitating anti-C4 antibody of anti-Rodgers specificity. Vox Sang. 1984;47:242–249
  26. Michel J, Sharon R. Non-haemolytic adverse reaction after transfusion of a blood unit containing penicillin. BMJ. 1980;280:152–153
  27. Branch DR, Gifford H. Allergic reaction to transfused cephalothin antibody. JAMA. 1979;241:495–496
  28. Johansson SG, Nopp A, van HM, et al. Passive IgE-sensitization by blood transfusion. Allergy. 2005;60:1192–1199
  29. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev. 1997;77:1033–1079
  30. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res. 2004;10:201–222
  31. Yamagata K, Matsumura K, Inoue W, et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci. 2001;21:2669–2677
  32. Mills EM, Rusyniak DE, Sprague JE. The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J Mol Med. 2004;82:787–799
  33. Blatteis CM, Li S, Li Z, et al. Cytokines, PGE2 and endotoxic fever: A re-assessment. Prostaglandins Other Lipid Mediat. 2005;76:1–18
  34. Brunton L, Lazo J, Parker K. Goodman & Gilman's the pharmacological basis of therapeutics. (11 ed.). New York: McGraw-Hill; 2005;
  35. Kaufman DW, Kelly JP, Rosenberg L, et al. Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. JAMA. 2002;287:337–344
  36. Kaplowitz N. Acetaminophen hepatoxicity: What do we know, what don't we know, and what do we do next?. Hepatology. 2004;40:23–26
  37. Lee WM. Acetaminophen and the U.S. Acute Liver Failure Study Group: Lowering the risks of hepatic failure. Hepatology. 2004;40:6–9
  38. Allmers H. Frequent acetaminophen use and allergic diseases: Is the association clear?. J Allergy Clin Immunol. 2005;116:859–862
  39. Casale TB, Blaiss MS, Gelfand E, et al. First do no harm: Managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol. 2003;111:S835–S842
  40. Weiler JM, Bloomfield JR, Woodworth GG, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000;132:354–363
  41. Finkle WD, Adams JL, Greenland S, et al. Increased risk of serious injury following an initial prescription for diphenhydramine. Ann Allergy Asthma Immunol. 2002;89:244–250
  42. Sharma AN, Hexdall AH, Chang EK, et al. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003;21:212–215
  43. Heddle NM, Klama LN, Griffith L, et al. A prospective study to identify the risk factors associated with acute reactions to platelet and red cell transfusions. Transfusion. 1993;33:794–797
  44. Wang SE, Lara PN, Lee-Ow A, et al. Acetaminophen and diphenhydramine as premedication for platelet transfusions: a prospective randomized double-blind placebo-controlled trial. Am J Hematol. 2002;70:191–194
  45. Buck SA, Kickler TS, McGuire M, et al. The utility of platelet washing using an automated procedure for severe platelet allergic reactions. Transfusion. 1987;27:391–393
  46. Perrotta PL, Snyder EL. Non-infectious complications of transfusion therapy. Blood Rev. 2001;15:69–83
  47. Hinson JA, Reid AB, McCullough SS, et al. Acetaminophen-induced hepatotoxicity: Role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev. 2004;36:805–822
  48. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: Hepatoxicity after multiple doses in children. J Pediatr. 1998;132:22–27
  49. Verster JC, Volkerts ER, van Oosterwijck AW, et al. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol. 2003;111:623–627
  50. O'Hanlon JF, Ramaekers JG. Antihistamine effects on actual driving performance in a standard test: A summary of Dutch experience, 1989-94. Allergy. 1995;50:234–242
  51. Da Ponte PA, Bidoli E, Talamini R, et al. Pre-storage leucocyte depletion and transfusion reaction rates in cancer patients. Transfus Med. 2005;15:37–43
  52. Couban S, Carruthers J, Andreou P, et al. Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reduction. Transfusion. 2002;42:753–758
  53. Heddle NM, Blajchman MA, Meyer RM, et al. A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced platelets. Transfusion. 2002;42:556–566
  54. Uhlmann EJ, Isgriggs E, Wallhermfechtel M, et al. Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions. Transfusion. 2001;41:997–1000
  55. Sarkodee-Adoo CB, Kendall JM, Sridhara R, et al. The relationship between the duration of platelet storage and the development of transfusion reactions. Transfusion. 1998;38:229–235
  56. Riccardi D, Raspollini E, Rebulla P, et al. Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats. Transfusion. 1997;37:528–530
  57. Anderson NA, Gray S, Copplestone JA, et al. A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: Corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions. Transfus Med. 1997;7:33–39
  58. Muylle L, Wouters E, Peetermans ME. Febrile reactions to platelet transfusion: the effect of increased interleukin 6 levels in concentrates prepared by the platelet-rich plasma method. Transfusion. 1996;36:886–890
  59. Federowicz I, Barrett BB, Andersen JW, et al. Characterization of reactions after transfusion of cellular blood components that are white cell reduced before storage. Transfusion. 1996;36:21–28
  60. Dzieczkowski JS, Barrett BB, Nester D, et al. Characterization of reactions after exclusive transfusion of white cell-reduced cellular blood components. Transfusion. 1995;35:20–25
  61. Oksanen K, Ebeling F, Kekomaki R, et al. Adverse reactions to platelet transfusions are reduced by use of platelet concentrates derived from buffy coat. Vox Sang. 1994;67:356–361
  62. Mangano MM, Chambers LA, Kruskall MS. Limited efficacy of leukopoor platelets for prevention of febrile transfusion reactions. Am J Clin Pathol. 1991;95:733–738
  63. Chambers LA, Kruskall MS, Pacini DG, et al. Febrile reactions after platelet transfusion: The effect of single versus multiple donors. Transfusion. 1990;30:219–221

 This work was supported by the American Lebanese Syrian Associated Charities and by the National Institutes of Health Cancer Center Support Grant CA-21765.

PII: S0887-7963(06)00091-5

doi: 10.1016/j.tmrv.2006.09.001

Transfusion Medicine Reviews
Volume 21, Issue 1 , Pages 1-12 , January 2007

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