Transfusion Medicine Reviews
Volume 21, Issue 4 , Pages 295-306 , October 2007

Past and Future Approaches to Assess the Quality of Platelets for Transfusion

  • Elisabeth Maurer-Spurej

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Elisabeth Maurer-Spurej, University of British Columbia, Life Sciences Centre 4.466, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.
    • ,
  • Kate Chipperfield

References 

  1. Murphy S. What's so bad about old platelets?. Transfusion. 2002;42:809–811
  2. Murphy S, Gardner FH. Effect of storage temperature on maintenance of platelet viability—Deleterious effect of refrigerated storage. N Engl J Med. 1969;280:1094–1098
  3. Murphy S, Sayar SN, Gardner FH. Storage of platelet concentrates at 22 degrees C. Blood. 1970;35:549–557
  4. AuBuchon JP, Herschel L, Roger J, et al. Preliminary validation of a new standard of efficacy for stored platelets. Transfusion. 2004;44:36–41
  5. Murphy S, Rebulla P, Bertolini F, et al. In vitro assessment of the quality of stored platelet concentrates. Transfus Med Rev. 1994;8:29–36
  6. Pietersz RN, Engelfriet CP, Reesink HW, et al. Evaluation of stored platelets. Vox Sang. 2004;86:203–223
  7. Cardigan R, Turner C, Harrison P. Current methods of assessing platelet function: Relevance to transfusion medicine. Vox Sang. 2005;88:153–163
  8. Kunicki TJ, Tuccelli M, Becker GA, et al. A study of variables affecting the quality of platelets stored at “room temperature”. Transfusion. 1975;15:414–421
  9. Rock G, Neurath D, Cober N, et al. Seven-day storage of random donor PLT concentrates. Transfusion. 2003;43:1374–1377
  10. Holme S, Sawyer S, Heaton A, et al. Studies on platelets exposed to or stored at temperatures below 20 degrees C or above 24 degrees C. Transfusion. 1997;37:5–11,1997
  11. Kim HK, Song KS, Lee ES, et al. Optimized flow cytometric assay for the measurement of platelet microparticles in plasma: Pre-analytic and analytic considerations. Blood Coagul Fibrinolysis. 2002;13:393–397
  12. Holme S, Moroff G, Murphy S. A multi-laboratory evaluation of in vitro platelet assays: The tests for extent of shape change and response to hypotonic shock. Transfusion. 1998;38:31–40
  13. Hunter S, Nixon J, Murphy S. The effect of the interruption of agitation on platelet quality during storage for transfusion. Transfusion. 2001;41:809–814
  14. Perrotta PL, Perrotta CL, Snyder EL. Apoptotic activity in stored human platelets. Transfusion. 2003;43:526–535
  15. Savage B, Cattaneo M, Ruggeri ZM. Mechanisms of platelet aggregation. Curr Opin Hematol. 2001;8:270–276
  16. Hartwig JH, Italiano JEJ. Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006;36:99–103
  17. White JG, Rao GH. Microtubule coils versus the surface membrane cytoskeleton in maintenance and restoration of platelet discoid shape. Am J Pathol. 1998;152:597–609
  18. Winokur R, Hartwig JH. Mechanism of shape change in chilled human platelets. Blood. 1995;85:1796–1804
  19. Devine DV, Bradley AJ, Maurer E, et al. Effects of prestorage white cell reduction on platelet aggregate formation and the activation state of platelets and plasma enzyme systems. Transfusion. 1999;39:724–734
  20. Barnard MR, MacGregor H, Ragno G, et al. Fresh, liquid-preserved, and cryopreserved platelets: Adhesive surface receptors and membrane procoagulant activity. Transfusion. 1999;39:880–888
  21. Bode AP, Hickerson DH. Characterization and quantitation by flow cytometry of membranous microparticles formed during activation of platelet suspensions with ionophore or thrombin. Platelets. 2000;11:259–271
  22. Bode AP, Orton SM, Frye MJ, et al. Vesiculation of platelets during in vitro aging. Blood. 1991;77:887–895
  23. Owens MR. The role of platelet microparticles in hemostasis. Transfus Med Rev. 1994;8:37–44
  24. Curvers J, van Pampus EC, Feijge MA, et al. Decreased responsiveness and development of activation markers of PLTs stored in plasma. Transfusion. 2004;44:49–58
  25. Tan KT, Tayebjee MH, Lim HS, et al. Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels. Diabet Med. 2005;22:1657–1662
  26. Horstman LL, Jy W, Jimenez JJ, et al. New horizons in the analysis of circulating cell-derived microparticles. Keio J Med. 2004;53:210–230
  27. Xiao HY, Matsubayashi H, Bonderman DP, et al. Generation of annexin V–positive platelets and shedding of microparticles with stimulus-dependent procoagulant activity during storage of platelets at 4 degrees C. Transfusion. 2000;40:420–427
  28. Chang CP, Zhao J, Wiedmer T, et al. Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine. J Biol Chem. 1993;268:7171–7178
  29. Nieuwland R, Sturk A. Platelet-derived microparticles. In:  Michelson AD editors. Platelets: Academic Press; 2002;p. 255–265
  30. Mollnes TE, Videm V, Christiansen D, et al. Platelet compatibility of an artificial surface modified with functionally active heparin. Thromb Haemost. 1999;82:1132–1136
  31. Bertolini F, Rebulla P, Porretti L, et al. Platelet quality after 15-day storage of platelet concentrates prepared from buffy coats and stored in a glucose-free crystalloid medium. Transfusion. 1992;32:9–16,1992
  32. Murphy S. Platelets from pooled buffy coats: An update. Transfusion. 2005;45:634–639
  33. Hagberg IA, Akkok CA, Lyberg T, et al. Apheresis-induced platelet activation: Comparison of three types of cell separators. Transfusion. 2000;40:182–192
  34. Arnold DM, Heddle NM, Kulczycky M, et al. In vivo recovery and survival of apheresis and whole blood–derived platelets: A paired comparison in healthy volunteers. Transfusion. 2006;46:257–264
  35. AuBuchon JP, Taylor H, Holme S, et al. In vitro and in vivo evaluation of leukoreduced platelets stored for 7 days in CLX containers. Transfusion. 2005;45:1356–1361
  36. Bertolini F, Murphy S. A multicenter inspection of the swirling phenomenon in platelet concentrates prepared in routine practice. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion. Transfusion. 1996;36:128–132
  37. Brecher ME, Hay SN. Platelet swirling. Transfusion. 2004;44:627,;2004
  38. Bellhouse EL, Inskip MJ, Davis JG, et al. Pre-transfusion non-invasive quality assessment of stored platelet concentrates. Br J Haematol. 1987;66:503–508
  39. Slichter SJ, Harker LA. Preparation and storage of platelet concentrates. II. Storage variables influencing platelet viability and function. Br J Haematol. 1976;34:403–419
  40. Slichter SJ, Harker LA. Preparation and storage of platelet concentrates. I. Factors influencing the harvest of viable platelets from whole blood. Br J Haematol. 1976;34:395–402
  41. Born GV. Adenosine diphosphate as a mediator of platelet aggregation in vivo. Adv Exp Med Biol. 1985;192:399–409
  42. Latimer P, Born GV, Michal F. Application of light-scattering theory to the optical effects associated with the morphology of blood platelets. Arch Biochem Biophys. 1977;180:151–159
  43. Maurer-Spurej E, Devine DV. Platelet aggregation is not initiated by platelet shape change. Lab Invest. 2001;81:1517–1525
  44. Fratantoni JC, Poindexter BJ, Bonner RF. Quantitative assessment of platelet morphology by light scattering: A potential method for the evaluation of platelets for transfusion. J Lab Clin Med. 1984;103:620–631
  45. David PJ, Nair AC, Menon VJ, et al. Laser light scattering studies from blood platelets and their aggregates. Colloids Surf B Biointerfaces. 1996;6:101–114
  46. Hubbell JA, Pohl PI, Wagner WR. The use of laser-light scattering and controlled shear in platelet aggregometry. Thromb Haemost. 1991;65:601–607
  47. Maurer-Spurej E, Pfeiler G, Maurer N, et al. Room temperature activates human blood platelets. Lab Invest. 2001;81:581–592
  48. Chapman ES, Sorette M, Hetherington E, et al. A rapid, automated flow cytometric method to measure activated degranulated platelets by density determination. Thromb Haemost. 2003;89:1004–1015
  49. Macey M, Azam U, McCarthy D, et al. Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine, and dipyridamole (CTAD) for assessing platelet activation on the ADVIA 120 hematology system. Clin Chem. 2002;48:891–899
  50. Corash L, Shafer B. Use of asplenic rabbits to demonstrate that platelet age and density are related. Blood. 1982;60:166–171
  51. Kelton JG, Denomme G. The quantitation of platelet-associated IgG on cohorts of platelets separated from healthy individuals by buoyant density centrifugation. Blood. 1982;60:136–139
  52. Eto K, Takeshita S, Ochiai M, et al. Platelet aggregation in acute coronary syndromes: use of a new aggregometer with laser light scattering to assess platelet aggregability. Cardiovasc Res. 1998;40:223–229
  53. Tomida Y, Iino S, Nishikawa M, et al. A new system to detect native microaggregates of platelets in vivo, with a novel platelet aggregometer employing laser light scattering. Thromb Res. 1998;92:221–228
  54. Lazarus AH, Wright JF, Blanchette V, et al. Analysis of platelets by flow cytometry. Transfus Sci. 1995;16:353–361
  55. Satoh K, Yatomi Y, Kubota F, et al. Small aggregates of platelets can be detected sensitively by a flow cytometer equipped with an imaging device: Mechanisms of epinephrine-induced aggregation and antiplatelet effects of beraprost. Cytometry. 2002;48:194–201
  56. Logean E, Schmetterer LF, Riva CE. Optical Doppler velocimetry at various retinal vessel depths by variation of the source coherence length. Appl Opt. 2000;39:2858–2862
  57. Mattley Y, Leparc G, Potter R, et al. Light scattering and absorption model for the quantitative interpretation of human blood platelet spectral data. Photochem Photobiol. 2000;71:610–619
  58. Ren H, Sun T, MacDonald DJ, et al. Real-time in vivo blood-flow imaging by moving-scatterer–sensitive spectral-domain optical Doppler tomography. Opt Lett. 2006;31:927–929
  59. Chayen N, Dieckmann M, Dierks K, et al. Size and shape determination of proteins in solution by a noninvasive depolarized dynamic light scattering instrument. Ann N Y Acad Sci. 2004;1027:20–27
  60. Gabriel DA, Reece NS, Li X, et al. Electrophoretic light scattering studies on the interaction of fibrinogen with resting and activated human platelets. Blood Coagul Fibrinolysis. 1993;4:397–403
  61. Spurej E, Glatter O, Pfeiler G. Shape change of human blood platelets: Reliable and fast detection by quasi-elastic light scattering. Experientia. 1992;48:71–79
  62. Maurer-Spurej E, Brown K, Labrie A, et al. Portable dynamic light scattering instrument and method for the measurement of blood platelet suspensions. Phys Med Biol. 2006;51:3747–3758
  63. Mbahi M, Reddy V, Narvios A. Transfusion medicine history illustrated. Milky platelet concentrate: A second look. Transfusion. 2006;46:877,;2006
  64. Rinder HM, Smith BR. In vitro evaluation of stored platelets: Is there hope for predicting posttransfusion platelet survival and function?. Transfusion. 2003;43:2–6
  65. Hawker RJ, Turner VS, Mitchell SG. Use of prostaglandin E1 during preparation of platelet concentrates. Transfus Med. 1996;6:249–254
  66. Becker GA, Tuccelli M, Kunicki T, et al. Studies of platelet concentrates stored at 22 C and 4 C. Transfusion. 1973;13:61–68
  67. Davis KB, Slichter SJ, Corash L. Corrected count increment and percent platelet recovery as measures of posttransfusion platelet response: Problems and a solution. Transfusion. 1999;39:586–592
  68. McCullough J, Vesole DH, Benjamin RJ, et al. Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: The SPRINT Trial. Blood. 2004;104:1534–1541
  69. Hervig T, Haugen T, Liseth K, et al. The platelet count accuracy of platelet concentrates obtained by using automated analysis is influenced by instrument bias and activated platelet components. Vox Sang. 2004;87:196–203
  70. Webert KE, Cook RJ, Couban S, et al. A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptoms. Transfusion. 2006;46:1926–1933
  71. Webert KE, Cook RJ, Sigoilin CS, et al. The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia. Haematologica. 2006;91:1530–1537
  72. Rinder HM, Snyder EL, Tracey JB, et al. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: Restoration of secretory function and maintenance of platelet survival. Transfusion. 2003;43:1230–1237
  73. Snyder EL, Ezekowitz M, Aster R, et al. Extended storage of platelets in a new plastic container. II. In vivo response to infusion of platelets stored for 5 days. Transfusion. 1985;25:209–214
  74. Murphy S. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion. 2004;44:618–619(letter)
  75. Dijkstra-Tiekstra MJ, Pietersz RN, Huijgens PC. Correlation between the extent of platelet activation in platelet concentrates and in vitro and in vivo parameters. Vox Sang. 2004;87:257–263
  76. Holme S, Vaidja K, Murphy S. Platelet storage at 22 degrees C: Effect of type of agitation on morphology, viability, and function in vitro. Blood. 1978;52:425–435
  77. VandenBroeke T, Dumont LJ, Hunter S, et al. Platelet storage solution affects on the accuracy of laboratory tests for platelet function: A multi-laboratory study. Vox Sang. 2004;86:183–188
  78. Snyder EL, Ezekowitz MD, Malech HL, et al. In vitro characteristics and in vivo viability of platelets contained in granulocyte-platelet apheresis concentrate. Transfusion. 1987;27:10–14
  79. Ringwald J, Althoff F, Zimmermann R, et al. Washing platelets with new additive solutions: Aspects on the in vitro quality after 48 hours of storage. Transfusion. 2006;46:236–243
  80. Dumont LJ, AuBuchon JP, Gulliksson H, et al. In vitro pH effects on in vivo recovery and survival of platelets: An analysis by the BEST Collaborative. Transfusion. 2006;46:1300–1305
  81. Goodrich RP, Li J, Pieters H, et al. Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects. Vox Sang. 2006;90:279–285
  82. Holme S, Heaton WA, Courtright M. Platelet storage lesion in second-generation containers: Correlation with platelet ATP levels. Vox Sang. 1987;53:214–220
  83. Holme S, Heaton WA, Smith KT, et al. Evaluation of apheresis platelet concentrates collected with a reduced (30-ml) collection chamber with resuspension and storage in a synthetic medium. Vox Sang. 1994;67:149–153
  84. Ringwald J, Zimmermann R, Strasser E, et al. Measuring the pH of platelet concentrates. Transfusion. 2006;46:870–871(letter)
  85. Janetzko K, Lin L, Eichler H, et al. Implementation of the INTERCEPT blood system for platelets into routine blood bank manufacturing procedures: Evaluation of apheresis platelets. Vox Sang. 2004;86:239–245

 The work was supported by the Canadian Blood Services (Vancouver, British Columbia, Canada).

PII: S0887-7963(07)00044-2

doi: 10.1016/j.tmrv.2007.05.005

Transfusion Medicine Reviews
Volume 21, Issue 4 , Pages 295-306 , October 2007

Article Tools

* Image Usage & Resolution