« Previous
Next »
Transfusion Medicine Reviews
Volume 22, Issue 3
, Pages 188-201
, July 2008
Toward a Molecular Explanation for Cross-presentation of Antigens to the Immune System
References
- . Donor leukocyte transfusions for treatment of leukemic relapse after bone marrow transplantation. EBMT Immunology and Chronic Leukemia Working Parties. Vox Sang. 1998;74(Suppl 2):321–329
- Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995;86:2041–2050
- Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol. 1997;15:433–444
- Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions. Biol Blood Marrow Transplant. 1999;5:253–261
- . Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol. 2005;5:296–306
- . The promise of cancer vaccines. Nat Rev Cancer. 2004;4:401–411
- Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med. 2004;10:1359–1365
- . The CTL's kiss of death. Cell. 1995;81:9–12
- . In: Cellular and molecular immunology. (ed 5). Philadelphia: Elsevier; 2005;p. 81–104
- . How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol. 1995;11:267–306
- . The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules. Nat Immunol. 2004;5:685–692
- . Generation of major histocompatibility complex class I antigens: Functional interplay between proteasomes and TPPII. Nat Immunol. 2004;5:661–669
- . Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004;5:670–677
- . Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol. 2001;1:126–134
- Herpes simplex virus type 2 induces rapid cell death and functional impairment of murine dendritic cells in vitro. J Virol. 2003;77:11139–11149
- . Human cytomegalovirus inhibits differentiation of monocytes into dendritic cells with the consequence of depressed immunological functions. J Virol. 2003;77:10943–10956
- . CD8+ T lymphocyte–mediated lysis of Chlamydia-infected L cells using an endogenous antigen pathway. J Immunol. 1994;153:4588–4595
- . Cells infected with Yersinia present an epitope to class I MHC–restricted CTL. J Immunol. 1994;153:1603–1612
- . Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules. Infect Immun. 1996;64:1870–1872
- . Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming. J Immunol. 1976;117:2233–2238
- . Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med. 1976;143:1283–1288
- . Cross-priming. Nat Immunol. 2006;7:363–365
- . Cross-presentation: Underlying mechanisms and role in immune surveillance. Immunol Rev. 2005;207:166–183
- . Priming of T cells by exogenous antigen cross-presented on MHC class I molecules. Curr Opin Immunol. 2006;18:85–91
- . Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science. 1990;249:918–921
- . MHC class I–restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo. J Immunol. 1992;148:13–18
- Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J Immunol. 1993;150:438–446
- Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A. 1993;90:4942–4946
- Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J Immunol. 1997;158:2723–2730
- CpG-DNA aided cross-priming by cross-presenting B cells. J Immunol. 2004;172:1501–1507
- B lymphocytes participate in cross-presentation of antigen following gene gun vaccination. J Immunol. 2005;174:5233–5242
- . Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes. J Immunol. 2005;174:5209–5214
- . Neutrophils process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes. J Immunol. 2001;167:2538–2546
- . Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens. J Immunol. 2004;173:1994–2002
- Neutrophils efficiently cross-prime naive T cells in vivo. Blood. 2007;110:2965–2973
- Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med. 2000;6:1348–1354
- Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway. J Immunol. 2005;174:7711–7715
- . Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells. J Immunol. 2005;175:2071–2081
- Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nat Immunol. 2002;3:265–271
- In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity. 2002;17:211–220
- Activation of lysosomal function during dendritic cell maturation. Science. 2003;299:1400–1403
- NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell. 2006;126:205–218
- Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005;307:1630–1634
- Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells. Nat Immunol. 2005;6:107–113
- . A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity. 2006;25:607–617
- . Outside looking in: The inner workings of the cross-presentation pathway within dendritic cells. Trends Immunol. 2007;28:45–47
- . Loading of MHC class I and II presentation pathways by exogenous antigens: A quantitative in vivo comparison. J Immunol. 2004;172:6129–6135
- Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries?. J Exp Med. 2000;192:F39–F44
- Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol. 2002;20:621–667
- Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1. J Immunol. 2003;170:4437–4440
- Epidermal viral immunity induced by CD8 alpha+ dendritic cells but not by Langerhans cells. Science. 2003;301:1925–1928
- Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses. J Immunol. 2004;172:1996–2000
- . Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(−) dendritic cells in vivo. J Exp Med. 2002;196:817–827
- . CD8(+) but not CD8(−) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med. 2000;192:1685–1696
- The CD8 alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med. 2002;196:1099–1104
- . Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8− dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol. 2001;166:5327–5330
- The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture. Proc Natl Acad Sci U S A. 2006;103:10729–10734
- . Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity. Trends Immunol. 2004;25:655–658
- . Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm. Semin Immunol. 2005;17:262–272
- Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I–restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci U S A. 2004;101:8670–8675
- Migratory dendritic cells transfer antigen to a lymph node–resident dendritic cell population for efficient CTL priming. Immunity. 2006;25:153–162
- . Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur J Immunol. 2002;32:155–162
- Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol. 2005;141:398–404
- . Cellular protein is the source of cross-priming antigen in vivo. Proc Natl Acad Sci U S A. 2004;101:3035–3040
- Antigen bias in T cell cross-priming. Science. 2004;304:1314–1317
- CD8+ T cell cross-priming via transfer of proteasome substrates. Science. 2004;304:1318–1321
- Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins. J Immunol. 2005;175:796–805
- Cutting edge: efficient MHC class I cross-presentation during early vaccinia infection requires the transfer of proteasomal intermediates between antigen donor and presenting cells. J Immunol. 2003;171:5668–5672
- . Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med. 1993;178:1391–1396
- Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. 1994;39:93–98
- . A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science. 1995;269:1585–1588
- Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. Traffic. 2002;3:358–366
- Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J Exp Med. 2000;191:1965–1974
- . Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules. J Biol Chem. 2001;276:17163–17171
- Heat shock protein–peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med. 1997;186:1315–1322
- Efficient cross-presentation by heat shock protein 90–peptide complex–loaded dendritic cells via an endosomal pathway. J Immunol. 2007;179:1803–1813
- . Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nat Immunol. 2005;6:593–599
- . Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins. J Immunol. 2004;173:5929–5933
- Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity. 1995;3:783–791
- . Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J Immunol. 1994;153:4925–4933
- . Class I–restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med. 1990;171:377–387
- Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol. 2001;166:6099–6103
- Mechanisms of MHC class I–restricted antigen processing and cross-presentation. Immunol Rev. 2005;207:145–157
- . A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science. 1995;267:243–246
- Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature. 1999;398:77–80
- Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nat Cell Biol. 1999;1:362–368
- Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell. 2002;110:119–131
- The phagosome proteome: Insight into phagosome functions. J Cell Biol. 2001;152:165–180
- . The efficiency of antigen delivery from macrophage phagosomes into cytoplasm for MHC class I-restricted antigen presentation. Vaccine. 1997;15:511–518
- . Cellular mechanisms governing cross-presentation of exogenous antigens. Nat Immunol. 2004;5:678–684
- ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 2003;425:397–402
- Phagosomes are competent organelles for antigen cross-presentation. Nature. 2003;425:402–406
- Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc Natl Acad Sci U S A. 2003;100:12889–12894
- Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell. 2005;123:157–170
- . Exiting the outside world for cross-presentation. Immunity. 2006;25:523–525
- . Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway. J Immunol. 1996;156:4182–4190
- Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity. 2004;21:155–165
- Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature. 1993;361:359–362
- . Bacterial proteins can be processed by macrophages in a transporter associated with antigen processing-independent, cysteine protease-dependent manner for presentation by MHC class I molecules. J Immunol. 2000;164:168–175
- . Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: Protein context influences the degree of TAP-independent presentation. Eur J Immunol. 1996;26:2790–2799
- TAP1-independent loading of class I molecules by exogenous viral proteins. Eur J Immunol. 1995;25:1739–1743
- Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I–restricted cytotoxic T cells. Eur J Immunol. 2002;32:1099–1108
- Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo. J Immunol. 2001;166:4355–4362
- Cross-presentation of virus-like particles by skin-derived CD8(−) dendritic cells: A dispensable role for TAP. Eur J Immunol. 2002;32:818–825
- Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain. Nat Immunol. 2003;4:1065–1073
- . The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol. 2006;176:6770–6776
- Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells. Int Immunol. 2005;17:45–53
- . Dendritic cells: open for presentation business. Nat Immunol. 2005;6:7–8
- Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science. 2007;316:612–616
- . Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules. Curr Opin Immunol. 2007;19:66–72
- Cross-presentation by intercellular peptide transfer through gap junctions. Nature. 2005;434:83–88
- Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol. 2007;178:6949–6957
- . Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med. 2003;198:111–122
- Control of cross-presentation during dendritic cell maturation. Eur J Immunol. 2004;34:398–407
- Enhanced dendritic cell antigen capture via Toll-like receptor–induced actin remodeling. Science. 2004;305:1153–1157
- Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat Immunol. 2006;7:165–172
- TLR ligands differentially affect uptake and presentation of cellular antigens. Blood. 2007;109:3890–3894
- Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity. Nat Med. 2001;7:625–629
- Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy. Cancer Res. 2004;64:5084–5088
- Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins. Vaccine. 2007;25:1452–1463
- Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med. 2002;196:947–955
- . Cross-priming versus cross-tolerance: Are two signals enough?. Trends Immunol. 2002;23:171–173
PII: S0887-7963(08)00013-8
doi: 10.1016/j.tmrv.2008.02.002
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Transfusion Medicine Reviews
Volume 22, Issue 3
, Pages 188-201
, July 2008
