Transfusion Medicine Reviews
Volume 22, Issue 4 , Pages 268-279 , October 2008

Platelet Storage Lesion: A New Understanding From a Proteomic Perspective

  • Jonathan N. Thon
  • ,
  • Peter Schubert
  • ,
  • Dana V. Devine

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Dana Devine, PhD, Vice President, Medical, Scientific and Research Affairs, Canadian Blood Services, UBC Centre for Blood Research, 4th Floor, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.

References 

  1. Page MJ, Griffiths TA, Bleackley MR, et al. Proteomics: Applications relevant to transfusion medicine. Transfus Med Rev. 2006;20:63–74
  2. Queloz PA, Thadikkaran L, Crettaz D, et al. Proteomics and transfusion medicine: Future perspectives. Proteomics. 2006;6:5605–5614
  3. Reddy KS, Perrotta PL. Proteomics in transfusion medicine. Transfusion. 2004;44:601–604
  4. Thadikkaran L, Siegenthaler MA, Crettaz D, et al. Recent advances in blood-related proteomics. Proteomics. 2005;5:3019–3034
  5. Issaq HJ, Xiao Z, Veenstra TD. Serum and plasma proteomics. Chem Rev. 2007;107:3601–3620
  6. Pasini EM, Kirkegaard M, Mortensen P, et al. In-depth analysis of the membrane and cytosolic proteome of red blood cells. Blood. 2006;108:791–801
  7. Garcia A, Prabhakar S, Brock CJ, et al. Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 2004;4:656–668
  8. Maguire PB, Wynne KJ, Harney DF, et al. Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics. 2002;2:642–648
  9. Perrotta PL, Bahou WF. Proteomics in platelet science. Curr Hematol Rep. 2004;3:462–469
  10. Marcus K, Immler D, Sternberger J, et al. Identification of platelet proteins separated by two-dimensional gel electrophoresis and analyzed by matrix assisted laser desorption/ionization–time of flight–mass spectrometry and detection of tyrosine-phosphorylated proteins. Electrophoresis. 2000;21:2622–2636
  11. O'Neill EE, Brock CJ, von Kriegsheim AF, et al. Towards complete analysis of the platelet proteome. Proteomics. 2002;2:288–305
  12. Martens L, Van Damme P, Van Damme J, et al. The human platelet proteome mapped by peptide-centric proteomics: A functional protein profile. Proteomics. 2005;5:3193–3204
  13. Garcia A, Prabhakar S, Hughan S, et al. Differential proteome analysis of TRAP-activated platelets: Involvement of DOK-2 and phosphorylation of RGS proteins. Blood. 2004;103:2088–2095
  14. Garcia A, Senis YA, Antrobus R, et al. A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: Involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics. 2006;6:5332–5343
  15. Moebius J, Zahedi RP, Lewandrowski U, et al. The human platelet membrane proteome reveals several new potential membrane proteins. Mol Cell Proteomics. 2005;4:1754–1761
  16. Garcia BA, Smalley DM, Cho H, et al. The platelet microparticle proteome. J Proteome Res. 2005;4:1516–1521
  17. Maynard DM, Heijnen HF, Home MK, et al. Proteomic analysis of platelet alpha-granules using mass spectrometry. J Thromb Haemost. 2007;5:1945–1955
  18. Hernandez-Ruiz L, Valverde F, Jimenez-Nunez MD, et al. Organellar proteomics of human platelet dense granules reveals that 14-3-3zeta is a granule protein related to atherosclerosis. J Proteome Res. 2007;6:4449–4457
  19. Zahedi RP, Begonja AJ, Gambaryan S, et al. Phosphoproteomics of human platelets: A quest for novel activation pathways. Biochim Biophys Acta. 2006;1764:1963–1976
  20. Lewandrowski U, Zahedi RP, Moebius J, et al. Enhanced N-glycosylation site analysis of sialoglycopeptides by strong cation exchange prefractionation applied to platelet plasma membranes. Mol Cell Proteomics. 2007;6:1933–1941
  21. Patel SR, Hartwig JH, Italiano JE. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005;115:3348–3354
  22. Aster RH. Pooling of platelets in the spleen: Role in the pathogenesis of “hypersplenic” thrombocytopenia. J Clin Invest. 1966;45:645–657
  23. Mason KD, Carpinelli MR, Fletcher JI, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007;128:1173–1186
  24. White JG. Electron microscopic studies of platelet secretion. Prog Hemostasis Thromb. 1974;2:49–98
  25. White JG. Interaction of membrane systems in blood platelets. Am J Pathol. 1972;66:295–312
  26. Cutler L, Rodan G, Feinstein MB. Cytochemical localization of adenylate cyclase and of calcium ion, magnesium ion–activated ATPases in the dense tubular system of human blood platelets. Biochim Biophys Acta. 1978;542:357–371
  27. White JG. Effects of colchicine and vinca alkaloids on human platelets. I. Influence on platelet microtubules and contractile function. Am J Pathol. 1968;53:281–291
  28. McRedmond JP, Park SD, Reilly DF, et al. Integration of proteomics and genomics in platelets: A profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics. 2004;3:133–144
  29. Gnatenko DV, Dunn JJ, McCorkle SR, et al. Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood. 2003;101:2285–2293
  30. Weyrich AS, Lindemann S, Tolley ND, et al. Change in protein phenotype without a nucleus: Translational control in platelets. Semin Thromb Hemost. 2004;30:491–498
  31. Weyrich AS, Zimmerman GA. Evaluating the relevance of the platelet transcriptome. Blood. 2003;102:1550–1551
  32. Lindemann S, Tolley ND, Eyre JR, et al. Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem. 2001;276:33947–33951
  33. Weyrich AS, Dixon DA, Pabla R, et al. Signal-dependent translation of a regulatory protein, Bc1-3, in activated human platelets. Proc Natl Acad Sci U S A. 1998;95:5556–5561
  34. Roth GJ, Hickey MJ, Chung DW, et al. Circulating human blood platelets retain appreciable amounts of poly (A)+ RNA. Biochem Biophys Res Commun. 1989;160:705–710
  35. Rosenwald IB, Pechet L, Han A, et al. Expression of translation initiation factors e1F-4E and e1F-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost. 2001;85:142–151
  36. Papkoff J, Chen RH, Blenis J, et al. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cell Biol. 1994;14:463–472
  37. Kieffer N, Guichard J, Farcet JP, et al. Biosynthesis of major platelet proteins in human blood platelets. Eur J Biochem. 1987;164:189–195
  38. Booyse FM, Rafelson ME. Studies on human platelets. I. Synthesis of platelet protein in a cell-free system. Biochim Biophys Acta. 1968;166:689–697
  39. Booyse F, Rafelson ME. In vitro incorporation of amino-acids into the contractile protein of human blood platelets. Nature. 1967;215:283–284
  40. Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol. 2001;154:485–490
  41. Gailani D, Renne T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:2507–2513
  42. Kolev K, Machovich R. Molecular and cellular modulation of fibrinolysis. Thromb Haemost. 2003;89:610–621
  43. Anitua E, Andia I, Ardanza B, et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91:4–15
  44. Sen CK. The general case for redox control of wound repair. Wound Repair Regen. 2003;11:431–438
  45. Slichter SJ. Controversies in platelet transfusion therapy. Annu Rev Med. 1980;31:509–540
  46. Higby DJ, Cohen E, Holland JF, et al. The prophylactic treatment of thrombocytopenic leukemic patients with platelets: A double blind study. Transfusion. 1974;14:440–446
  47. Solomon J, Bofenkamp T, Fahey JL, et al. Platelet prophylaxis in acute non-lymphoblastic leukaemia. Lancet. 1978;1:267
  48. Stanworth SJ, Hyde C, Brunskill S, et al. Platelet transfusion prophylaxis for patients with haematological malignancies: where to now?. Br J Haematol. 2005;131:588–595
  49. White GC. Congenital and acquired platelet disorders: Current dilemmas and treatment strategies. Semin Hematol. 2006;43:S37–S41
  50. Mayer SA, Rincon F. Ultra-early hemostatic therapy for acute intracerebral hemorrhage. Semin Hematol. 2006;43:S70–S76
  51. Murphy S, Gardner FH. Platelet storage at 22 degrees C: Role of gas transport across plastic containers in maintenance of viability. Blood. 1975;46:209–218
  52. Anderson KC, Lew MA, Gorgone BC, et al. Transfusion-related sepsis after prolonged platelet storage. Am J Med. 1986;81:405–411
  53. Heal JM, Singal S, Sardisco E, et al. Bacterial proliferation in platelet concentrates. Transfusion. 1986;26:388–390
  54. Hillyer CD, Josephson CD, Blajchman MA, et al. Bacterial contamination of blood components: Risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. Hematology Am Soc Hematol Educ Program. 2003;575–589
  55. Blajchman MA, Goldman M, Baeza F. Improving the bacteriological safety of platelet transfusions. Transfus Med Rev. 2004;18:11–24
  56. Brecher ME, Hay SN. Bacterial contamination of blood components. Clin Microbiol Rev. 2005;18:195–204
  57. Blajchman MA, Beckers EA, Dickmeiss E, et al. Bacterial detection of platelets: Current problems and possible resolutions. Transfus Med Rev. 2005;19:259–272
  58. Eder AF, Kennedy JM, Dy BA, et al. Bacterial screening of apheresis platelets and the residual risk of septic transfusion reactions: The American Red Cross experience (2004-2006). Transfusion. 2007;47:1134–1142
  59. de Korte D, Curvers J, de Kort WL, et al. Effects of skin disinfection method, deviation bag, and bacterial screening on clinical safety of platelet transfusions in the Netherlands. Transfusion. 2006;46:476–485
  60. Castro E, Girones N, Bueno JL, et al. The efficacy of photochemical treatment with amotosalen HC1 and ultraviolet A (INTERCEPT) for inactivation of Trypanosoma cruzi in pooled buffy-coat platelets. Transfusion. 2007;47:434–441
  61. Sawyer L, Hanson D, Castro G, et al. Inactivation of parvovirus B19 in human platelet concentrates by treatment with amotosalen and ultraviolet A illumination. Transfusion. 2007;47:1062–1070
  62. Lozano M, Galan A, Mazzara R, et al. Leukoreduced buffy coat-derived platelet concentrates photochemically treated with amotosalen HC1 and ultraviolet A light stored up to 7 days: Assessment of hemostatic function under flow conditions. Transfusion. 2007;47:666–671
  63. Nussbaumer W, Allersdorfer D, Grabmer C, et al. Prevention of transfusion of platelet components contaminated with low levels of bacteria: A comparison of bacteria culture and pathogen inactivation methods. Transfusion. 2007;47:1125–1133
  64. Cardigan R, Williamson LM. The quality of platelets after storage for 7 days. Transfus Med. 2003;13:173–187
  65. Evaluation of stored platelets. Vox Sang. 2004;86:203–223
  66. Fratantoni JC, Sturdivant B, Poindexter BJ. Aberrant morphology of platelets stored in five day containers. Thromb Res. 1984;33:607–615
  67. Holme S, Murphy S. Quantitative measurements of platelet shape by light transmission studies; application to storage of platelets for transfusion. J Lab Clin Med. 1978;92:53–64
  68. Holme S, Murphy S. Coulter counter and light transmission studies of platelets exposed to low temperature, ADP, EDTA, and storage at 22 degrees. J Lab Clin Med. 1980;96:480–493
  69. Ray V, Chaudhary R, Singh H. Modified CMI, an essential adjunct to CMI of platelet for quality control during preparation and storage of platelet concentrates. Transfus Apher Sci. 2003;29:147–149
  70. Holme S, Murphy S. Platelet storage at 22 degrees C for transfusion: Interrelationship of platelet density and size, medium pH, and viability after in vivo infusion. J Lab Clin Med. 1983;101:161–174
  71. Rao AK, Niewiarowski S, Murphy S. Acquired granular pool defect in stored platelets. Blood. 1981;57:203–208
  72. Rinder HM, Snyder EL, Bonan JL, et al. Activation in stored platelet concentrates: Correlation between membrane expression of P-selectin, glycoprotein IIb/IIIa, and beta-thromboglobulin release. Transfusion. 1993;33:25–29
  73. Bode AP, Orton SM, Frye MJ, et al. Vesiculation of platelets during in vitro aging. Blood. 1991;77:887–895
  74. George JN. Platelet membrane glycoproteins: Alternations during storage of human platelet concentrates. Thrombosis Research. 1976;8:719–724
  75. George JN, Pickett EB, Heinz R. Platelet membrane glycoprotein changes during the preparation and storage of platelet concentrates. Transfusion. 1988;28:123–126
  76. George JN, Pickett EB, Saucerman S, et al. Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery. J Clin Invest. 1986;78:340–348
  77. Jennings LK, Ashmun RA, Wang WC, et al. Analysis of human platelet glycoproteins IIb-IIIa and Glanzmann's thrombasthenia in whole blood by flow cytometry. Blood. 1986;68:173–179
  78. Cardigan R, Turner C, Harrison P. Current methods of assessing platelet function: Relevance to transfusion medicine. Vox Sang. 2005;88:153–163
  79. Maurer-Spurej E, Chipperfield K. Past and future approaches to assess the quality of platelets for transfusion. Transfus Med Rev. 2007;21:295–306
  80. Akay OM, Gunduz E, Basyigit H, et al. Platelet function testing during 5-day storage of single and random donor plateletpheresis. Transfus Apher Sci. 2007;36:285–289
  81. Dekkers DW, De Cuyper IM, van der Meer PF, et al. Influence of pH on stored human platelets. Transfusion. 2007;47:1889–1895
  82. Holme S, Heaton A, Roodt J. Concurrent label method with 111In and 51Cr allows accurate evaluation of platelet viability of stored platelet concentrates. Br J Haematol. 1993;84:717–723
  83. Peter-Salonen K, Bucher U, Nydegger UE. Comparison of posttransfusion recoveries achieved with either fresh or stored platelet concentrates. Blut. 1987;54:207–212
  84. Murphy S, Kahn RA, Holme S, et al. Improved storage of platelets for transfusion in a new container. Blood. 1982;60:194–200
  85. Simon TL, Nelson EJ, Carmen R, et al. Extension of platelet concentrate storage. Transfusion. 1983;23:207–212
  86. Schiffer CA, Lee EJ, Ness PM, et al. Clinical evaluation of platelet concentrates stored for one to five days. Blood. 1986;67:1591–1594
  87. Hogge DE, Thompson BW, Schiffer CA. Platelet storage for 7 days in second-generation blood bags. Transfusion. 1986;26:131–135
  88. Arnold DM, Heddle NM, Kulczycky M, et al. In vivo recovery and survival of apheresis and whole blood–derived platelets: A paired comparison in healthy volunteers. Transfusion. 2006;46:257–264
  89. Vasconcelos E, Figueiredo AC, Seghatchian J. Quality of platelet concentrates derived by platelet rich plasma, buffy coat and apheresis. Transfus Apher Sci. 2003;29:13–16
  90. Snyder EL, Dunn BE, Giometti CS, et al. Protein changes occurring during storage of platelet concentrates. A two-dimensional gel electrophoretic analysis. Transfusion. 1987;27:335–341
  91. Ong SE, Mann M. Mass spectrometry–based proteomics turns quantitative. Nat Chem Biol. 2005;1:252–262
  92. Thiele T, Steil L, Gebhard S, et al. Profiling of alterations in platelet proteins during storage of platelet concentrates. Transfusion. 2007;47:1221–1233
  93. Li J, Xia Y, Bertino AM, et al. The mechanism of apoptosis in human platelets during storage. Transfusion. 2000;40:1320–1329
  94. Seghatchian J, Krailadsiri P. Platelet storage lesion and apoptosis: Are they related?. Transfus Apher Sci. 2001;24:103–105
  95. Glenister KM, Payne KA, Sparrow RL. Proteomic analysis of supernatant from pooled buffy-coat platelet concentrates throughout 7-day storage. Transfusion. 2007;48:99–107
  96. Thon JN, Schubert P, Duguay M, et al. Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches. Transfusion. 2008;48:425–435
  97. Thon JN, Devine DV. Translation of glycoprotein IIIa in stored blood platelets. Transfusion. 2007;47:2260–2270
  98. Dale GL. Coated-platelets: An emerging component of the procoagulant response. J Thromb Haemost. 2005;3:2185–2192
  99. Orr AW, Pallero MA, Xiong WC, et al. Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem. 2004;279:48983–48992
  100. Kinoshita M. Diversity of septin scaffolds. Curr Opin Cell Biol. 2006;18:54–60
  101. Hall PA, Russell SE. The pathobiology of the septin gene family. J Pathol. 2004;204:489–505
  102. Kato K, Martinez C, Russell S, et al. Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood. 2004;104:2339–2344
  103. Bode A. Platelet activation may explain the storage lesion in platelet concentrates. Blood Cells. 1990;16:109–125
  104. Wu WW, Wang G, Baek SJ, et al. Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOF. J Proteome Res. 2006;5:651–658
  105. Zieske LR. A perspective on the use of iTRAQ reagent technology for protein complex and profiling studies. J Exp Bot. 2006;57:1501–1508
  106. Righetti PG, Castagna A, Antonioli P, et al. Prefractionation techniques in proteome analysis: The mining tools of the third millennium. Electrophoresis. 2005;26:297–319
  107. Watson SP, Bahou WF, Fitzgerald D, et al. Mapping the platelet proteome: A report of the ISTH Platelet Physiology Subcommittee. J Thromb Haemost. 2005;3:2098–2101
  108. Gnatenko DV, Perrotta PL, Bahou WF. Proteomic approaches to dissect platelet function: Half the story. Blood. 2006;108:3983–3991
  109. Svendsen MS, Rojkjaer R, Kristensen AT, et al. Impairment of the hemostatic potential of platelets during storage as evaluated by flow cytometry, thrombin generation, and thrombelastography under conditions promoting formation of coated platelets. Transfusion. 2007;47:2057–2065
  110. Rinder HM, Snyder EL. Activation of platelet concentrate during preparation and storage. Blood Cells. 1992;18:445–456
  111. Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004;103:2096–2104
  112. Zucker MB, Borrelli J. Reversible alterations in platelet morphology produced by anticoagulants and by cold. Blood. 1954;9:602–608
  113. Maurer-Spurej E, Pfeiler G, Maurer N, et al. Room temperature activates human blood platelets. Lab Invest. 2001;81:581–592
  114. Hoffmeister KM, Felbinger TW, Falet H, et al. The clearance mechanism of chilled blood platelets. Cell. 2003;112:87–97
  115. Hoffmeister KM, Josefsson EC, Isaac NA, et al. Glycosylation restores survival of chilled blood platelets. Science. 2003;301:1531–1534
  116. Wandall HH, Hoffmeister KM, Sorensen AL, et al. Galactosylation does not prevent the rapid clearance of long-term 4°C stored platelets. Blood. 2008;111:3249–3256
  117. Ringwald J, Zimmermann R, Eckstein R. The new generation of platelet additive solution for storage at 22 degrees C: Development and current experience. Transfus Med Rev. 2006;20:158–164
  118. de Wildt-Eggen J, Nauta S, Schrijver JG, et al. Reactions and platelet increments after transfusion of platelet concentrates in plasma or an additive solution: A prospective, randomized study. Transfusion. 2000;40:398–403
  119. Corash L. Inactivation of viruses, bacteria, protozoa and leukocytes in platelet and red cell concentrates. Vox Sang. 2000;78(Suppl 2):205–210
  120. Goodrich RP. The use of riboflavin for the inactivation of pathogens in blood products. Vox Sang. 2000;78(Suppl 2):211–215
  121. Ruane PH, Edrich R, Gampp D, et al. Photochemical inactivation of selected viruses and bacteria in platelet concentrates using riboflavin and light. Transfusion. 2004;44:877–885
  122. Slichter SJ. Platelet transfusion therapy. Hematol Oncol Clin North Am. 2007;21:697–729

 JNT and PS contributed equally to this work.

PII: S0887-7963(08)00040-0

doi: 10.1016/j.tmrv.2008.05.004

Transfusion Medicine Reviews
Volume 22, Issue 4 , Pages 268-279 , October 2008