Transfusion Medicine Reviews
Volume 23, Issue 2 , Pages 155-159 , April 2009

Severe Hemolytic Anemia Post–Renal Transplantation Produced by Donor Anti-D Passenger Lymphocytes: Case Report and Literature Review

References 

  1. Pomper GJ, Joseph RA, Hartmann EL, et al. Massive immune hemolysis caused by anti-D after dual kidney transplantation. Am J Transplant. 2005;5:2586–2589
  2. Ramsey G. Red cell antibodies arising from solid organ transplants. Transfusion. 1991;31:76–86
  3. Petz LD. Immune hemolysis associated with transplantation. Semin Hematol. 2005;42:145–155
  4. Ramsey G, Israel L, Lindsay GD, et al. Anti-Rho(D) in two Rh-positive patients receiving kidney grafts from an Rh-immunized donor. Transplantation. 1986;41:67–69
  5. Solheim BG, Albrechtsen D, Egeland T, et al. Auto-antibodies against erythrocytes in transplant patients produced by donor lymphocytes. Transplant Proc. 1987;19:4520–4521
  6. Solheim BG, Albrechtsen D, Berg KJ, et al. Hemolytic anemia in cyclosporine-treated recipients of kidney or heart grafts from donors with minor incompatibility for ABO antigens. Transplant Proc. 1987;19:4236–4238
  7. Albrechtsen D, Solheim BG, Flatmark A, et al. Autoimmune hemolytic anemia in cyclosporine-treated organ allograft recipients. Transplant Proc. 1988;20(Suppl 3):959–962
  8. Swanson J, Sebring E, Sastamoinen R, et al. Gm allotyping to determine the origin of the anti-D causing hemolytic anemia in a kidney transplant recipient. Vox Sang. 1987;52:228–230
  9. Frohn C, Jabs WJ, Fricke L, et al. Hemolytic anemia after kidney transplantation: Case report and differential diagnosis. Ann Hematol. 2002;81:158–160
  10. Saba NF, Sweeney JD, Penn LC, et al. Anti-D in a D-positive renal transplant patient. Transfusion. 1997;37:321–324
  11. Schwartz D, Gotzinger P. Immune haemolytic anaemia (IHA) after solid organ transplantation due to Rhesus antibodies of donor origin: Report of 5 cases. Beitr Infusionther. 1992;30:367–369
  12. Knoop C, Andrien M, Antoine M, et al. Severe hemolysis due to a donor anti-D antibody after heart-lung transplantation. Association with lung and blood chimerism. Am Rev Respir Dis. 1993;148:504–506
  13. Sindhi R, Landmark J, Stratta RJ, et al. Humoral graft-versus-host disease after pancreas transplantation with an ABO-compatible and Rh-nonidentical donor. Case report and a rationale for preoperative screening. Transplantation. 1996;61:1414–1416
  14. Ramsey G, Kiss JE, Sacher RA, et al. In: Rh antibodies in two patients receiving liver and kidney-pancreas grafts from the same Rh-sensitized donor. Paper presented at the Joint Congress of the American Association of Blood Banks and the International Society of Blood Transfusion. Los Angeles, CA November 10-15, 1990. Book of Abstracts. Arlington, VA: American Association of Blood Banks; 1990;p. 198
  15. Fung MK, Sheikh H, Eghtesad B, et al. Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant. Transfusion. 2004;44:1635–1639
  16. Lee JH, Mintz PD. Graft versus host anti-Rho(D) following minor Rh-incompatible orthotopic liver transplantation. Am J Hematol. 1993;44:168–171
  17. Flesland O, Solheim BG, Bergan A. Red cell antibody production due to primary immune response by lymphoid tissue in a grafted liver. Transpl Immunol. 1993;1:86–87
  18. Calhoun B, Pothiawala M, Musa G, et al. Indicators of clinically significant red cell antibodies produced by sensitized lymphocytes in liver transplant patients. Immunohematol. 1991;7:37–39
  19. Shortt J, Westall GP, Roxby D, et al. A ‘dangerous’ group O donor: Severe hemolysis in all recipients of organs from a donor with multiple red cell alloantibodies. Am J Transplant. 2008;8:711–714
  20. Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science. 2002;298:2199–2202
  21. Manz RA, Thiel A, Radbruch A. Lifetime of plasma cells in the bone marrow. Nature. 1997;388:133–134
  22. Cassese G, Lindenau S, de Boer B, et al. Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur J Immunol. 2001;31:2726–2732

PII: S0887-7963(08)00109-0

doi: 10.1016/j.tmrv.2008.12.005

Transfusion Medicine Reviews
Volume 23, Issue 2 , Pages 155-159 , April 2009

Article Tools

* Image Usage & Resolution