Transfusion Medicine Reviews
Volume 23, Issue 4 , Pages 266-283, October 2009

The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury

  • Yoke Lin Fung

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Lin Fung, Research and Development, Australian Red Cross Blood Service, PO Box 145, Kelvin Grove, QLD 4059, Australia.
    • ,
  • Christopher C. Silliman

Australian Red Cross Blood Service, Brisbane, Queensland, Australia

Bonfils Blood Center and the Department of Pediatrics and Surgery, University of Colorado Denver, Aurora, CO

Transfusion-related acute lung injury (TRALI) is the major cause of transfusion related morbidity and mortality, world wide. Efforts to reduce or eliminate this serious complication of blood transfusion are hampered by an incomplete understanding of its pathogenesis. Currently, TRALI is thought to be mediated by donor alloantibodies directed against host leukocytes or the result of 2 distinct clinical events. For both proposed mechanisms, the neutrophil is the key effector cell. This article reviews TRALI pathophysiology, explores the role of the neutrophil, details practical information for appropriate diagnosis and promotes further studies into the pathogenesis of TRALI.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 This work was supported by the Australian Red Cross Blood Service, the Bonfils Blood Center, and grants GM49222 from NIGMS and HL59355 from NHLBI, NIH (CCS).

PII: S0887-7963(09)00055-8

doi:10.1016/j.tmrv.2009.06.001

Transfusion Medicine Reviews
Volume 23, Issue 4 , Pages 266-283, October 2009

Article Tools

* Image Usage & Resolution