Transfusion Medicine Reviews
Volume 23, Issue 4 , Pages 247-254 , October 2009

Editorial: “Formula-Driven” Versus “Lab-Driven” Massive Transfusion Protocols: At a State of Clinical Equipoise

  • Jeannie L. Callum

      Affiliations

    • Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    • Corresponding Author InformationAddress reprint requests to Jeannie L. Callum, BA, MD, FRCPC, CTBS, Transfusion Medicine and Tissue Banks, Sunnybrook Health Sciences Centre, B211, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5.
  • ,
  • Bartolomeu Nascimento

      Affiliations

    • Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
  • ,
  • Homer Tien

      Affiliations

    • Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    • Canadian Forces Health Services, Toronto, ON, Canada
  • ,
  • Sandro Rizoli

      Affiliations

    • Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

References 

  1. Malone DL, Hess JR, Fingerhut A. Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. J Trauma. 2006;60:S91–S96
  2. Johansson PI, Hansen MB, Sorensen H. Transfusion practice in massively bleeding patients: Time for a change?. Vox Sang. 2005;89:92–96
  3. Stansbury LG, Dutton RP, Stein DM, et al. Controversy in trauma resuscitation: Do ratios of plasma to red blood cells matter?. Transfus Med Rev. 2009;23:255–265
  4. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63:805–813
  5. Zink KA, Sambasivan CN, Holcomb JB, et al. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009;197:565–570
  6. Scalea TM, Bochicchio KM, Lumpkins K, et al. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg. 2008;248:578–584
  7. Zehtabchi S, Nishijima DK. Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe trauma. Acad Emerg Med. 2009;16:371–378
  8. Maegele M, Lefering R, Paffrath T, et al. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: A retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang. 2008;95:112–119
  9. Snyder CW, Weinberg JA, McGwin G, et al. The relationship of blood product ratio to mortality: Survival benefit or survival bias?. J Trauma. 2009;66:358–364
  10. Acosta JA, Yang JC, Winchell RJ, et al. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg. 1998;186:528–533
  11. Guss DA, Meyer FT, Neuman TS, et al. The impact of a regionalized trauma system on trauma care in San Diego County. Ann Emerg Med. 1989;18:1141–1145
  12. Shackford SR, Hollingworth-Fridlund P, Cooper GF, et al. The effect of regionalization upon the quality of trauma care as assessed by concurrent audit before and after institution of a trauma system: A preliminary report. J Trauma. 1986;26:812–820
  13. Sperry JL, Ochoa JB, Gunn SR, et al. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008;65:986–993
  14. Cotton BA, Au BK, Nunez TC, et al. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66:41–49
  15. Toulon P, Ozier Y, Ankri A, et al. Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery: A multicenter study. Thromb Haemost. 2009;101:394–401
  16. Churchill WH, Schmidt B, Lindsey J, et al. Thawing fresh frozen plasma in a microwave oven. A comparison with thawing in a 37 degrees C waterbath. Am J Clin Pathol. 1992;97:227–232
  17. Spinella PC, Perkins JG, Grathwohl KW, et al. Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries. J Trauma. 2008;64:S69–S78
  18. Dickinson KJ, Troxler M, Homer-Vanniasin S. The surgical application of point-of-care haemostasis and platelet function testing. British Journal of Surgery. 2008;95:1317–1330
  19. Mathias Haun, Personal communication, Canadian Blood Services.
  20. Wright SE, Snowden CP, Athey SC. et al. Acute lung injury after ruptured abdominal aortic aneurysm repair: The effect of excluding donations from females from the production of fresh frozen plasma. Crit Care Med. 2008;36:1796–1802
  21. Brohi K, Singh J, Heron M, et al. Acute traumatic coagulopathy. J Trauma. 2003;54:1127–1130
  22. Cotton BA, Gunter OL, Isbell J, et al. Damage control hematology: The impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008;64:1177–1183
  23. MacLeod JBA, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39–44
  24. Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62:112–119
  25. Cotton BA, Guy JS, Morris JA, et al. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006;26:115–121
  26. Teixeira PGR, Inaba K, Shulman I, et al. Impact of plasma transfusion in massively transfused trauma patients. J Trauma. 2009;1:693–697
  27. Canadian Standards Association . CSA Z902: Blood and Blood Components. Canadian Standards Association; 2004;
  28. American Association of Blood Banks . Standards for Blood Banks and Transfusion Services. ed 24. Bethesda (Md): American Association of Blood Banks; 2006;
  29. Flesland O. A comparison of complication rates based on published haemovigilance data. Intensive Care Med. 2007;33:S17–S21[Suppl 1]
  30. Prowse C. Properties of pathogen-inactivated plasma components. Transfus Med Rev. 2009;23:124–133
  31. Yuan S, Ziman A, Anthony MA, et al. How do we provide blood products to trauma patients?. Transfusion. 2009;[Electronic publication ahead of print 2009 Mar 10]
  32. Wallis JP, Dzik S. Is fresh frozen plasma overtransfused in the United States?. Transfusion. 2004;44:1674–1675
  33. Fung MK, Downes KA, Shulman IA. Transfusion of platelets containing ABO-incompatible plasma: A survey of 3156 North American laboratories. Arch Pathol Lab Med. 2007;131:909–916
  34. Sadani DT, Urbaniak SJ, Bruce M, et al. Repeat ABO-incompatible platelet transfusions leading to hemolytic transfusion reaction. Transfus Med. 2006;16:375–379
  35. Andreu G, Vasse J, Hervé F, et al. Introduction en pratique transfusionnelle des concentrés de plaquettes en solution de conservation: Avantages, inconvénients, et intérêt pour les patients. Transfus Clin Biol. 2007;14:100–106[Electronic publication 2007 May 23]
  36. Johansson PI, Stensballe J, Rosenberg I, et al. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: Evaluating a change in transfusion practice. Transfusion. 2007;47:593–598
  37. Forcione DG, Alam HB, Kalva SP, et al. Case 9-2009: An 81-year-old man with massive rectal bleeding. N Engl J Med. 2009;360:1239–1248

PII: S0887-7963(09)00062-5

doi: 10.1016/j.tmrv.2009.06.007

Transfusion Medicine Reviews
Volume 23, Issue 4 , Pages 247-254 , October 2009